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Complaints of pain observed in 25% – 50% of elderly people living at home and from 45% to 80% living in institutions in which they are given a long uhod.1-6 untreated pain has serious consequences, which include depression, decreased socialization, sleep disturbance , violation of legal capacity, slowing recovery and rising health care costs. / 3,7,8 /.
Recommendations for survey
Although patients aged 60-70 years are able to report and assess signs of pain, but evaluation of pain in patients most venerable age may be complicated by their complex conditions and situations. Complicated circumstances include loss of vision and hearing, cognitive disturbances associated with delirium, dementia and other neurological diseases, cultural barriers and false belief, such as the fact that pain is an inevitable part of aging. / 2,7,9-12 /
In the past ten years there have been several studies that have been devoted to assessing the best ways to assess pain in elderly lyudey/.10-14 / / Many of the elderly did not accurately respond to questions about pain. However, the elderly with impaired cognitive abilities and skills, disorganized speech, have difficulty in describing their discomfort and may be unable to comprehend the agonizing pain, which prevents obsledovaniyu.7, 9,11,13 In one study of elderly patients with hip fracture who were violated the cognitive and verbal skills, have difficulties with the localization of pain and said that they “hurt everywhere.” “15 In other cases, the patients experienced pain and discomfort, but a negative answer to a question regarding boli.15 However, compared with controls, they are equally likely to report the presence of pain,” yes “or” no. “
The key to optimal treatment is the identification of pain. Health workers and staff should use the pain assessment tools that are simple, easily accessible, printed big and bold letters and in a language that patients understand / 12,14,16 /. We recommend using a verbal descriptive scale (The Verbal Descriptor Scale – VDS) because it uses the familiar words (slight pain, mild pain, moderate pain, severe pain, extreme pain and the pain is so strong as it can be) / .14 /. In two studies, the scale was considered the preferred and most easily understood by the elderly in communities / 15 /. In addition, she was seen approximately 73% of hospitalized older people with cognitive disabilities vozmozhnostyami/.15.
Recommendations of the American Geriatric Society (American Geriatric Society – AGS) also recommend the use of synonyms pain: pain, pressure, burning, lumbagos, compression, inflammation, neudobstvo.16 Studies have shown that, despite the fact that the visual analogue scale (Visual Analog Scales – VAS) and categorical scale (such as VDS) is closely correlated with each other, there is wide variation in VAS responses for each category and the overlap between the categories of indicators / 14 /.
Were developed some new methods of examination have not spoken to and severely damaged starikov/11 ,13,17-21. These methods include general observation which drew attention to the following behavior: movement of persons (faces, nahmurivanie, inflating the cheeks), specific of the body (grinding, fixing, obereganie, dotragivanie) and voice (cries, screams, cries) / 11,13,17-21 /. The researchers encourage the documentation of other forms of pain: poor appetite, depressive symptoms, sleep disturbances, functional disability, agitated behavior, resisting care, rejecting behavior and crying. / 9,11,13,17 /
Since the elderly with cognitive impairment can forget about the pain, if they are sitting quietly, a good strategy is to check during the movement and palpirovanie suspicious oblasti/21, 22. Consult with your family on the patient’s previous history of pain and use of analgesics / 15,21 / /
Older people with impaired cognition, aggressive or agitated behavior and resistance to care may be associated with untreated pain / 21-24 /. Preliminary study of aggressive elderly with cognitive impairment document the level of aggression are greatly increased in subjects diagnosed with arthritis or those who have two or more of diagnosis, which can cause boli/21. New behavioral changes in patients with dementia may signal that many medical problems, including urinary tract infections, constipation, changes in the heart and discomfort as a result of falls or injuries. Pilot studies empirical application of pain medication to reduce the aggressiveness yielded some success. These studies showed that treatment of pain can reduce the use of tranquilizers prescribed for the treatment of aggressive behavior / 23,24 /.
Recommendations for treatment
American Gerontological Society has published practical recommendations for the treatment of chronic pain in older people 1998 / 16 /. Some psychological changes with aging affect the treatment of chronic pain in the elderly, frail patients. These features include slow absorption of medications, metabolic disorders and processes of elimination. These features create problems associated with excessive sedation, disorientation, constipation and urinary retention / 16,25,26 /.
American Medical Directors Association (American Medical Directors Association-AMDA) in 1999 published guidelines for the treatment of chronic pain in older / 25 /. These recommendations promote the following principles of treatment of pain:
To the extent possible, use the least invasive (oral) route destination analgesics.
Identifying the causes of pain is necessary to select the best.
Cautious approach would help avoid having excessive sedation / 26 /.
The principles of the recommendations of the AGS and AMDA introduced by discussing the following circumstances.
Short-acting Analgesics are good for acute illness or sudden acute exacerbation of chronic illness. Atsetoaminofen drug of choice to alleviate the acute and moderate pain. Regularly appointed atsetoaminofen more effective than if he is appointed as needed. Often the elderly come to the nurse practitioner, complaining of pain, but they have not tried the application atsetoaminofena in a dose of 325 mg. Patients who say atsetoaminofen “not working” should be encouraged to use the dose from 650 mg to 1,000 mg three – four times a day, if they do not have a history of alcoholism or liver disease.
The daily prescription medications can be “ahead of” the emergence of problems with pain and maintain functional activity. Keep in mind the empirical purpose of pain therapy for deeply affected, being home patients who are experiencing pain and asking for help / 23,24 /. If we take comfort main objective empirical therapy will help achieve this goal. In one study testing atsetoaminofena at a dose of 650 mg three times daily for 10 home residents with difficulties in behavior led to a 63% reduction of behavioral symptoms / 24 /.
The dose of acetaminophen should not exceed 4 grams in 24 hours. This threshold can be easily exceeded if the drug is given as needed. Keep in mind the differences in dosages of acetaminophen in combined acetaminophen-opioid drugs. For example, acetaminophen with codeine (Tylenol # 3) contains 325 mg of acetaminophen, 1 tablet, oxycodone (oxycodone) acetaminophen (Percocet) and hydrocodone (hydrocodone) and acetaminophen (Vicoden) contains 500 mg and propoxyphene napsylate with acetaminophen (Darvocet N100) contains 650 mg of acetaminophen in 1 tablet.
NSAIDs (Nonsteroidal antiinflammatory drugs-NSAID) to be appointed by the elderly with care, especially with regard to patients with impaired renal function receiving anticoagulation therapy and bleeding in anamneze/16. Recommendations AGS advised to avoid long-term use of any NSAID, especially in high doses and in the form of long-acting drugs (such as naproxen sodium; Naprosyn, Aleve) due to increased risk of gastric ulcer bleeding / 16 /. Assign short-drugs (eg ibuprofen) in small doses (400 mg) for adults who require nonsteroidal anti-inflammatory preparaty/26. The medicine should be taken with meals, and course of treatment should be short-lived / 26 /.
Recommendations AGS warn against the simultaneous appointment of more than one NSAID. With extreme caution should be used NSAID in patients who take oral corticosteroids. Some observations indicate that the 14-day course of 400 mg of ibuprofen brings a more significant relief and improve function in elderly osteoarthritis knee or bedra/27. Such a short course of treatment may be useful in exacerbations of arthritis. However, prolonged treatment at high doses can lead to swelling of the lower limbs, gastric bleeding and renal dysfunction / 26 /.
The recent removal of rofecoxib from the market (rofecoxib-Vioxx) due to increased risk of cardiovascular episodes, as well as similar questions about other COX-2 inhibitors, confirms the need to avoid their use in the elderly / 28 /. This group of drugs inhibits the production of prostaglandins associated with inflammation and gives fewer gastrointestinal adverse reactions than the older pain relievers / 25,28 /. Nephrotoxicity, hypertension, and edema – the usual side effects of NSAID and they also are associated with COX-2 inhibitor. In determining the dosage of NSAID in the elderly should monitor renal function.
Opioid analgesic drugs (morphine, codeine, gidromorfan, hydrocodone, oxycodone) are useful for relief of moderate to severe pain. Unlike atsetoaminofena, opioid funds may titrate doses to achieve the effect, if they are not part of the combined drugs. However, the combination drugs that include atsetoaminofen have a limit as the limit “ceiling” dose of acetaminophen is 4 grams per day. Opioid funds available in the form of many drugs. Selecting the drug depends largely on the strength of pain, medical and cognitive status and tolerance to side effects / 16,25,26 /.
Continuing pain should be treated dlitelnodeystvuyuschimi or slow to eliminate drugs. Slow to eliminate drugs should be appointed at the initial high doses and should not be appointed opioid “naive” patients. Routine doses of drugs to titrate short-range, rising and allowing the patient to move to a long-acting drugs. Requires a good understanding of morphine equivalency. For example, a dose of 5 mg of liquid concentrate of morphine every 4 – 6 hours will be “ekvianalgetichna” one dose of oxycodone (oxycodone) and hydrocodone-atseaminofen (hydrocodone-acetaminophen) tablet over the same intervals.
The dose of morphine can concentrate stepwise increase to obtain relief.
However, side effects such as constipation, sedation, violations of recognition and instability when walking can be a contraindication to achieve the necessary dosage for pain relief / 25,26 /. Start with a low dose and gradually increase to track the side effects. Constipation can be combated with the help of laxatives. A simple approach such as the appointment of cherry flavored liquid acetaminophen (which can cause diarrhea), with oral morphine concentrate (which causes constipation) opens the way to balance the side effects of the assignment anlgetikov central and peripheral deystviya.15
Neuropathic pain is often described as “shooting” and the searing pain.
Tricyclic antidepressants (nortriptyline [Pamelor], desipramine (desipramine 0 [Norpramin]) and proivosudorozhnye drugs gabapentin – (gabapentin 0 [Neurontin]) in general are most effective for treating this type of pain than traditional pain relievers. Gabapentin (Gabapentin) may be effective for reduce neuropathic cancer pain in patients who receive treatment opioidami./29 / Gabapentin has a low profile of side effects, unlike the high-profile in anticholinergic tricyclic antidepressants (which can increase levels of anxiety and confusion in patients with mild dementia with). Recommendations AGS advised to apply carbamazepine (carbamazepine – Tegretol) in trigeminal neuralgia / 16,26 / /
By achieving comfort
Pain is a frustrating (frustrating) problem for the elderly and infirm patients. The combination of routine use of drugs, careful monitoring and additional non-pharmacological approaches recommended in order to achieve that sense of comfort for the patient.

Complaints of pain observed in 25% – 50% of elderly people living at home and from 45% to 80% living in institutions in which they are given a long uhod.1-6 untreated pain has serious consequences, which include depression, decreased socialization, sleep disturbance , violation of legal capacity, slowing recovery and rising health care costs. / 3,7,8 /.

Recommendations for survey

Although patients aged 60-70 years are able to report and assess signs of pain, but evaluation of pain in patients most venerable age may be complicated by their complex conditions and situations. Complicated circumstances include loss of vision and hearing, cognitive disturbances associated with delirium, dementia and other neurological diseases, cultural barriers and false belief, such as the fact that pain is an inevitable part of aging. / 2,7,9-12 /

In the past ten years there have been several studies that have been devoted to assessing the best ways to assess pain in elderly lyudey/.10-14 / / Many of the elderly did not accurately respond to questions about pain. However, the elderly with impaired cognitive abilities and skills, disorganized speech, have difficulty in describing their discomfort and may be unable to comprehend the agonizing pain, which prevents obsledovaniyu.7, 9,11,13 In one study of elderly patients with hip fracture who were violated the cognitive and verbal skills, have difficulties with the localization of pain and said that they “hurt everywhere.” “15 In other cases, the patients experienced pain and discomfort, but a negative answer to a question regarding boli.15 However, compared with controls, they are equally likely to report the presence of pain,” yes “or” no. ”

The key to optimal treatment is the identification of pain. Health workers and staff should use the pain assessment tools that are simple, easily accessible, printed big and bold letters and in a language that patients understand / 12,14,16 /. We recommend using a verbal descriptive scale (The Verbal Descriptor Scale – VDS) because it uses the familiar words (slight pain, mild pain, moderate pain, severe pain, extreme pain and the pain is so strong as it can be) / .14 /. In two studies, the scale was considered the preferred and most easily understood by the elderly in communities / 15 /. In addition, she was seen approximately 73% of hospitalized older people with cognitive disabilities vozmozhnostyami/.15.

Recommendations of the American Geriatric Society (American Geriatric Society – AGS) also recommend the use of synonyms pain: pain, pressure, burning, lumbagos, compression, inflammation, neudobstvo.16 Studies have shown that, despite the fact that the visual analogue scale (Visual Analog Scales – VAS) and categorical scale (such as VDS) is closely correlated with each other, there is wide variation in VAS responses for each category and the overlap between the categories of indicators / 14 /.

Were developed some new methods of examination have not spoken to and severely damaged starikov/11 ,13,17-21. These methods include general observation which drew attention to the following behavior: movement of persons (faces, nahmurivanie, inflating the cheeks), specific of the body (grinding, fixing, obereganie, dotragivanie) and voice (cries, screams, cries) / 11,13,17-21 /. The researchers encourage the documentation of other forms of pain: poor appetite, depressive symptoms, sleep disturbances, functional disability, agitated behavior, resisting care, rejecting behavior and crying. / 9,11,13,17 /

Since the elderly with cognitive impairment can forget about the pain, if they are sitting quietly, a good strategy is to check during the movement and palpirovanie suspicious oblasti/21, 22. Consult with your family on the patient’s previous history of pain and use of analgesics / 15,21 / /

Older people with impaired cognition, aggressive or agitated behavior and resistance to care may be associated with untreated pain / 21-24 /. Preliminary study of aggressive elderly with cognitive impairment document the level of aggression are greatly increased in subjects diagnosed with arthritis or those who have two or more of diagnosis, which can cause boli/21. New behavioral changes in patients with dementia may signal that many medical problems, including urinary tract infections, constipation, changes in the heart and discomfort as a result of falls or injuries. Pilot studies empirical application of pain medication to reduce the aggressiveness yielded some success. These studies showed that treatment of pain can reduce the use of tranquilizers prescribed for the treatment of aggressive behavior / 23,24 /.

Recommendations for treatment

American Gerontological Society has published practical recommendations for the treatment of chronic pain in older people 1998 / 16 /. Some psychological changes with aging affect the treatment of chronic pain in the elderly, frail patients. These features include slow absorption of medications, metabolic disorders and processes of elimination. These features create problems associated with excessive sedation, disorientation, constipation and urinary retention / 16,25,26 /.

American Medical Directors Association (American Medical Directors Association-AMDA) in 1999 published guidelines for the treatment of chronic pain in older / 25 /. These recommendations promote the following principles of treatment of pain:

To the extent possible, use the least invasive (oral) route destination analgesics.

Identifying the causes of pain is necessary to select the best.

Cautious approach would help avoid having excessive sedation / 26 /.

The principles of the recommendations of the AGS and AMDA introduced by discussing the following circumstances.

Short-acting Analgesics are good for acute illness or sudden acute exacerbation of chronic illness. Atsetoaminofen drug of choice to alleviate the acute and moderate pain. Regularly appointed atsetoaminofen more effective than if he is appointed as needed. Often the elderly come to the nurse practitioner, complaining of pain, but they have not tried the application atsetoaminofena in a dose of 325 mg. Patients who say atsetoaminofen “not working” should be encouraged to use the dose from 650 mg to 1,000 mg three – four times a day, if they do not have a history of alcoholism or liver disease.

The daily prescription medications can be “ahead of” the emergence of problems with pain and maintain functional activity. Keep in mind the empirical purpose of pain therapy for deeply affected, being home patients who are experiencing pain and asking for help / 23,24 /. If we take comfort main objective empirical therapy will help achieve this goal. In one study testing atsetoaminofena at a dose of 650 mg three times daily for 10 home residents with difficulties in behavior led to a 63% reduction of behavioral symptoms / 24 /.

The dose of acetaminophen should not exceed 4 grams in 24 hours. This threshold can be easily exceeded if the drug is given as needed. Keep in mind the differences in dosages of acetaminophen in combined acetaminophen-opioid drugs. For example, acetaminophen with codeine (Tylenol # 3) contains 325 mg of acetaminophen, 1 tablet, oxycodone (oxycodone) acetaminophen (Percocet) and hydrocodone (hydrocodone) and acetaminophen (Vicoden) contains 500 mg and propoxyphene napsylate with acetaminophen (Darvocet N100) contains 650 mg of acetaminophen in 1 tablet.

NSAIDs (Nonsteroidal antiinflammatory drugs-NSAID) to be appointed by the elderly with care, especially with regard to patients with impaired renal function receiving anticoagulation therapy and bleeding in anamneze/16. Recommendations AGS advised to avoid long-term use of any NSAID, especially in high doses and in the form of long-acting drugs (such as naproxen sodium; Naprosyn, Aleve) due to increased risk of gastric ulcer bleeding / 16 /. Assign short-drugs (eg ibuprofen) in small doses (400 mg) for adults who require nonsteroidal anti-inflammatory preparaty/26. The medicine should be taken with meals, and course of treatment should be short-lived / 26 /.

Recommendations AGS warn against the simultaneous appointment of more than one NSAID. With extreme caution should be used NSAID in patients who take oral corticosteroids. Some observations indicate that the 14-day course of 400 mg of ibuprofen brings a more significant relief and improve function in elderly osteoarthritis knee or bedra/27. Such a short course of treatment may be useful in exacerbations of arthritis. However, prolonged treatment at high doses can lead to swelling of the lower limbs, gastric bleeding and renal dysfunction / 26 /.

The recent removal of rofecoxib from the market (rofecoxib-Vioxx) due to increased risk of cardiovascular episodes, as well as similar questions about other COX-2 inhibitors, confirms the need to avoid their use in the elderly / 28 /. This group of drugs inhibits the production of prostaglandins associated with inflammation and gives fewer gastrointestinal adverse reactions than the older pain relievers / 25,28 /. Nephrotoxicity, hypertension, and edema – the usual side effects of NSAID and they also are associated with COX-2 inhibitor. In determining the dosage of NSAID in the elderly should monitor renal function.

Opioid analgesic drugs (morphine, codeine, gidromorfan, hydrocodone, oxycodone) are useful for relief of moderate to severe pain. Unlike atsetoaminofena, opioid funds may titrate doses to achieve the effect, if they are not part of the combined drugs. However, the combination drugs that include atsetoaminofen have a limit as the limit “ceiling” dose of acetaminophen is 4 grams per day. Opioid funds available in the form of many drugs. Selecting the drug depends largely on the strength of pain, medical and cognitive status and tolerance to side effects / 16,25,26 /.

Continuing pain should be treated dlitelnodeystvuyuschimi or slow to eliminate drugs. Slow to eliminate drugs should be appointed at the initial high doses and should not be appointed opioid “naive” patients. Routine doses of drugs to titrate short-range, rising and allowing the patient to move to a long-acting drugs. Requires a good understanding of morphine equivalency. For example, a dose of 5 mg of liquid concentrate of morphine every 4 – 6 hours will be “ekvianalgetichna” one dose of oxycodone (oxycodone) and hydrocodone-atseaminofen (hydrocodone-acetaminophen) tablet over the same intervals.

The dose of morphine can concentrate stepwise increase to obtain relief.

However, side effects such as constipation, sedation, violations of recognition and instability when walking can be a contraindication to achieve the necessary dosage for pain relief / 25,26 /. Start with a low dose and gradually increase to track the side effects. Constipation can be combated with the help of laxatives. A simple approach such as the appointment of cherry flavored liquid acetaminophen (which can cause diarrhea), with oral morphine concentrate (which causes constipation) opens the way to balance the side effects of the assignment anlgetikov central and peripheral deystviya.15

Neuropathic pain is often described as “shooting” and the searing pain.

Pamelor

Tricyclic antidepressants (nortriptyline [Pamelor], desipramine (desipramine 0 [Norpramin]) and proivosudorozhnye drugs gabapentin – (gabapentin 0 [Neurontin]) in general are most effective for treating this type of pain than traditional pain relievers. Gabapentin (Gabapentin) may be effective for reduce neuropathic cancer pain in patients who receive treatment opioidami./29 / Gabapentin has a low profile of side effects, unlike the high-profile in anticholinergic tricyclic antidepressants (which can increase levels of anxiety and confusion in patients with mild dementia with). Recommendations AGS advised to apply carbamazepine (carbamazepine – Tegretol) in trigeminal neuralgia / 16,26 / /

By achieving comfort

Pain is a frustrating (frustrating) problem for the elderly and infirm patients. The combination of routine use of drugs, careful monitoring and additional non-pharmacological approaches recommended in order to achieve that sense of comfort for the patient.

Pharmacological action
Base antirheumatic drug. Has antiproliferative, immunomodulatory (immunosuppressive) and anti-inflammatory effect. The active metabolite of leflunomide A771726 inhibits the enzyme degidroorotat dehydrogenase and has an antiproliferative effect. A771726 inhibits in vitro cell proliferation caused by mitogens and DNA synthesis of T-lymphocytes. Antiproliferative activity A771726 seen, apparently at the level of pyrimidine biosynthesis, since the addition of cell culture eliminates the inhibitory effect of uridine metabolite A771726. With the use of radioisotope ligand shown that A771726 selectively binds to the enzyme degidroorotat dehydrogenase, which explains its properties this enzyme and inhibit proliferation of lymphocytes at the stage of G1. Simultaneously A771726 inhibits the expression of receptors for interleukin-2 and core antigen Ki-67 and PCNA, associated with the cell cycle.
Therapeutic effect of leflunomide has been shown in several experimental models of autoimmune diseases, including rheumatoid arthritis.
Pharmacokinetics
The absorption and distribution
After oral administration, absorbed 82-95% of the drug. Eating does not affect the absorption leflunamida. Leflunomide is rapidly metabolized with the formation of the active metabolite A771726. Cmax metabolite A771726 determined within 1-24 h after a single dose of the dose. In plasma A771726 rapidly binds to albumin. Untie A771726 fraction is 0.62%. Binding A771726 more variable and somewhat reduced in patients with rheumatoid arthritis or chronic renal insufficiency.
Due to the long T1 / 2 A771726 was used a loading dose of 100 mg for 3 days. Pharmacokinetic parameters A771726 have a linear dependence at doses from 5 mg to 25 mg. In these studies, the clinical effect is closely related to plasma concentration of A771726 and a daily dose of leflunomide. At a dose of 20 mg / day, mean plasma concentration of A771726 at steady-state was 35 micrograms / ml.
Metabolism
Leflunomide is rapidly metabolized in the intestinal wall and liver to one of the main (A771726) metabolite and several secondary metabolites, including 4-trifluorometilalanin. Biotransformation of leflunomide to A771726 and A771726 of the subsequent metabolism are controlled by several enzymes and occur in microsomal and other cell fractions.
Withdrawal
In plasma, urine and feces determined by the trace amounts of leflunomide. Removing A771726 slow and characterized by clearance of 31 mL / h. T1 / 2 – about 2 weeks.
Pharmacokinetics in special clinical cases
Patients on hemodialysis, elimination of the drug quickly and T1 / 2 is shorter.
Data on the pharmacokinetics in patients with liver failure are absent.
Pharmacokinetics in patients younger than 18 years has not been studied.
Elderly patients (65 years and older) pharmacokinetic data correspond approximately to the middle age group.
Indications
- As the reference drug for the treatment of active rheumatoid arthritis to reduce symptoms and delay the development of structural damage of joints.
Dosage regimen
Treatment is initiated with the appointment of a shock dose of 100 mg daily for 3 days. As a maintenance dose prescribed dose of 10 mg to 20 mg 1 time per day.
The therapeutic effect is evident after 4-6 weeks of admission and may grow within 4-6 months.
Tablets should be swallowed whole, drinking plenty of fluids.
Not require dose adjustment for patients older than 65 years.
There are currently no recommendations for dosing regime for patients with mild renal insufficiency.
Side effects
Classification of the alleged frequency of side effects: typical – 1-10%, atypical – 0.1-1%, rare – 0.01-0.1%, very rare – 0.01% or less.
Since the cardiovascular system: typical – increase blood pressure.
From the digestive system: typical – diarrhea, nausea, vomiting, anorexia, lesions of the oral mucosa (thrush, mouth ulceration), abdominal pain, increased hepatic transaminases (particularly ALT, rarely – GGT, alkaline phosphatase, bilirubin); rarely – hepatitis, jaundice, cholestasis, very rarely – liver failure, acute liver necrosis.
On the part of the musculoskeletal system: typical – abscess, atypical – the gap ligaments.
Dermatological reactions: typical – hair loss, eczema, dry skin, atypical – Stevens-Johnson syndrome, Lyell syndrome, erythema multiforme.
The part of the hemopoietic system: typical – leukopenia (white blood cells more 2000/mkl); atypical – anemia, thrombocytopenia (platelets less than 100 000/mkl); rarely – eosinophilia, leukopenia (leukocytes less 2000/mkl), pancytopenia, very rarely – agranulocytosis. The risk of hematologic disorders increases with the recent, concomitant and subsequent application of myelotoxic drugs.
Allergic reactions: typical – rash (including makulo-papular), pruritus; atypical – urticaria; very rare – anaphylactic reactions.
On the part of the exchange processes: hyperlipidemia, hypophosphatemia, reduced levels of uric acid. Laboratory data (not clinically confirmed) showed a modest increase lactate dehydrogenase, creatine phosphokinase.
Other: very rarely – the development of severe infection and sepsis may develop rhinitis, bronchitis and pneumonia. In the application of immunosuppressive drugs increases the risk of cancer and some lymphoproliferative processes.
We can not exclude the possibility of a reversible reduction of sperm concentration, total sperm count and motility.
Contraindications
- Human liver;
- Severe immunodeficiency (including AIDS);
- Pronounced disorders of bone marrow hematopoiesis or anemia, leukopenia, thrombocytopenia due to other causes (other than rheumatoid arthritis);
- Infection heavy flow;
- Moderate or severe renal insufficiency (because of the small experience of clinical observations);
- Severe hypoproteinemia (including with nephrotic syndrome);
- Pregnancy;
- Lactation (breastfeeding);
- Childhood and adolescence to 18 years;
- Hypersensitivity to the ingredients.
The drug is contraindicated in women of childbearing age who do not use adequate contraception.
Pregnancy and lactation
The drug should not be administered during pregnancy and women of childbearing age who are not using reliable contraception. You must verify the absence of pregnancy before starting treatment.
In experimental studies have found that the drug may have fetotoksicheskoe and teratogenic effect.
Patients should be informed that suspected pregnancy should seek medical advice immediately and do a pregnancy test. If the test is positive, the physician should inform the patient about the possible risk to the fetus.
Women who take leflunomide and want to become pregnant (or already in the ensuing pregnancy) procedure is recommended to launch the drug, which will rapidly reduce the concentration of leflunomide and its metabolite in blood plasma (after cessation of treatment prescribed leflunomide kolestiramin in a dose of 8 g 3 times / day within 11 days or 50 g of activated charcoal, crushed into powder, 4 times / day for 11 days).
Next, you need to determine the concentration of metabolite A771726 2 times with an interval of 14 days. From the moment when the concentration of the drug will be fixed below 20 mg / l until fertilization should take 1.5 months.
Note that without the procedure of removing the drug, reduced metabolite concentrations below 20 ug / l occurs in 2 years.
Kolestiramin and activated carbon can affect the absorption of estrogen and progesterone in such a way that reliable oral contraceptives do not guarantee the necessary contraception during launch preparation. It is recommended to use alternative methods of contraception.
Studies in animals have shown that leflunomide or its metabolites are excreted in breast milk milk. Therefore, the need to designate a lactation should resolve the issue of termination of breastfeeding.
There is currently no information confirming the link between taking the drug Arava men and fetotoksicheskim action of the drug. Experimental studies in this direction were made. However, men receiving leflunomide therapy, should be warned of the possible effect of fetotoksicheskom and the need to use adequate contraception. To minimize risk when planning pregnancy should stop taking leflunomide and use kolestiramin to 8 mg 3 times daily for 11 days or 50 grams of powdered activated charcoal 4 times daily for 11 days.
Cautions
Note that the drug Arava may be imposed only after a medical examination (including before starting treatment and during treatment should monitor blood pressure).
Before treatment drug Arava should be mindful of possible increase in the number of side effects in patients previously treated with other basic tools for the treatment of rheumatoid arthritis, which have hepato-and gematotoksicheskim action.
The active metabolite of leflunomide A771726 characterized by long T1 / 2. Therefore, side effects can occur even after cessation of therapy. If you have any similar cases of toxicity or when moving to another base receiving the drug after treatment with leflunomide should be the procedure of removing the drug (after the cessation of leflunomide treatment prescribed kolestiramin in a dose of 8 g 3 times daily for 11 days or 50 g of activated carbon, crushed to powder, 4 times / day for 11 days).
Note that during the development of severe dermatologic adverse reactions, severe infections receiving the drug Arava should stop and immediately initiate the removal of the drug.
Need to monitor patients with tuberculin reactivity due to the risk of activating tuberculosis.
Given the long-term elimination of Arava is not recommended to vaccinate live vaccines against a background of leflunomide treatment.
Overdose
No data on overdose of leflunomide. Admission leflunomide 100 mg daily for 14 days was observed in 10 healthy volunteers. Two of them were removed after a week because of the increased level of transaminases in the blood plasma.
In case of overdose or toxicity is recommended to use kolestiramina or powdered activated carbon. Kolestiramin, take 3 healthy volunteers administered orally to 8 mg 3 times / day during the day, reduced levels of A771726 in plasma by approximately 40% after 24 h and 49-65% after 48 h.
Shown that introduction of activated charcoal orally or via oral gavage (50 mg every 6 hours during the day) reduced the concentration of the active metabolite A771726 in plasma by 37% after 24 h and 48% after 48 h.
Perhaps repetition procedures are preparation for clinical indications.
Drug Interactions
Increased adverse reactions may occur in the case of recent or concomitant use of hepatotoxic drugs or hematotoxicity or when receiving these drugs after starting leflunomide treatment procedure without removing the drug.
Not observed pharmacokinetic interaction between leflunomide (10-20 mg / day) and methotrexate (10-25 mg / week).
Unknown clinically significant interactions with concomitant use of leflunomide and triphasic oral contraceptives, NSAIDs, cimetidine, rifampicin.
Studies in vitro showed that the metabolite of leflunomide A771726 inhibits the activity of cytochrome P450 2C9. Therefore, caution should be prescribed the drug Arava with drugs metabolized by this enzyme system (phenytoin, warfarin, tolbutamide).
Conditions and terms of storage
The product should be stored at temperatures not above 25 ° C. Shelf life – 3 years.
Conditions of supply of pharmacies
The drug is released with a prescription.

Arava

Pharmacological action

Base antirheumatic drug. Has antiproliferative, immunomodulatory (immunosuppressive) and anti-inflammatory effect. The active metabolite of leflunomide A771726 inhibits the enzyme degidroorotat dehydrogenase and has an antiproliferative effect. A771726 inhibits in vitro cell proliferation caused by mitogens and DNA synthesis of T-lymphocytes. Antiproliferative activity A771726 seen, apparently at the level of pyrimidine biosynthesis, since the addition of cell culture eliminates the inhibitory effect of uridine metabolite A771726. With the use of radioisotope ligand shown that A771726 selectively binds to the enzyme degidroorotat dehydrogenase, which explains its properties this enzyme and inhibit proliferation of lymphocytes at the stage of G1. Simultaneously A771726 inhibits the expression of receptors for interleukin-2 and core antigen Ki-67 and PCNA, associated with the cell cycle.

Therapeutic effect of leflunomide has been shown in several experimental models of autoimmune diseases, including rheumatoid arthritis.

Pharmacokinetics

The absorption and distribution

After oral administration, absorbed 82-95% of the drug. Eating does not affect the absorption leflunamida. Leflunomide is rapidly metabolized with the formation of the active metabolite A771726. Cmax metabolite A771726 determined within 1-24 h after a single dose of the dose. In plasma A771726 rapidly binds to albumin. Untie A771726 fraction is 0.62%. Binding A771726 more variable and somewhat reduced in patients with rheumatoid arthritis or chronic renal insufficiency.

Due to the long T1 / 2 A771726 was used a loading dose of 100 mg for 3 days. Pharmacokinetic parameters A771726 have a linear dependence at doses from 5 mg to 25 mg. In these studies, the clinical effect is closely related to plasma concentration of A771726 and a daily dose of leflunomide. At a dose of 20 mg / day, mean plasma concentration of A771726 at steady-state was 35 micrograms / ml.

Metabolism

Leflunomide is rapidly metabolized in the intestinal wall and liver to one of the main (A771726) metabolite and several secondary metabolites, including 4-trifluorometilalanin. Biotransformation of leflunomide to A771726 and A771726 of the subsequent metabolism are controlled by several enzymes and occur in microsomal and other cell fractions.

Withdrawal

In plasma, urine and feces determined by the trace amounts of leflunomide. Removing A771726 slow and characterized by clearance of 31 mL / h. T1 / 2 – about 2 weeks.

Pharmacokinetics in special clinical cases

Patients on hemodialysis, elimination of the drug quickly and T1 / 2 is shorter.

Data on the pharmacokinetics in patients with liver failure are absent.

Pharmacokinetics in patients younger than 18 years has not been studied.

Elderly patients (65 years and older) pharmacokinetic data correspond approximately to the middle age group.

Indications

- As the reference drug for the treatment of active rheumatoid arthritis to reduce symptoms and delay the development of structural damage of joints.

Dosage regimen

Treatment is initiated with the appointment of a shock dose of 100 mg daily for 3 days. As a maintenance dose prescribed dose of 10 mg to 20 mg 1 time per day.

The therapeutic effect is evident after 4-6 weeks of admission and may grow within 4-6 months.

Tablets should be swallowed whole, drinking plenty of fluids.

Not require dose adjustment for patients older than 65 years.

There are currently no recommendations for dosing regime for patients with mild renal insufficiency.

Side effects

Classification of the alleged frequency of side effects: typical – 1-10%, atypical – 0.1-1%, rare – 0.01-0.1%, very rare – 0.01% or less.

Since the cardiovascular system: typical – increase blood pressure.

From the digestive system: typical – diarrhea, nausea, vomiting, anorexia, lesions of the oral mucosa (thrush, mouth ulceration), abdominal pain, increased hepatic transaminases (particularly ALT, rarely – GGT, alkaline phosphatase, bilirubin); rarely – hepatitis, jaundice, cholestasis, very rarely – liver failure, acute liver necrosis.

On the part of the musculoskeletal system: typical – abscess, atypical – the gap ligaments.

Dermatological reactions: typical – hair loss, eczema, dry skin, atypical – Stevens-Johnson syndrome, Lyell syndrome, erythema multiforme.

The part of the hemopoietic system: typical – leukopenia (white blood cells more 2000/mkl); atypical – anemia, thrombocytopenia (platelets less than 100 000/mkl); rarely – eosinophilia, leukopenia (leukocytes less 2000/mkl), pancytopenia, very rarely – agranulocytosis. The risk of hematologic disorders increases with the recent, concomitant and subsequent application of myelotoxic drugs.

Allergic reactions: typical – rash (including makulo-papular), pruritus; atypical – urticaria; very rare – anaphylactic reactions.

On the part of the exchange processes: hyperlipidemia, hypophosphatemia, reduced levels of uric acid. Laboratory data (not clinically confirmed) showed a modest increase lactate dehydrogenase, creatine phosphokinase.

Other: very rarely – the development of severe infection and sepsis may develop rhinitis, bronchitis and pneumonia. In the application of immunosuppressive drugs increases the risk of cancer and some lymphoproliferative processes.

We can not exclude the possibility of a reversible reduction of sperm concentration, total sperm count and motility.

Contraindications

- Human liver;

- Severe immunodeficiency (including AIDS);

- Pronounced disorders of bone marrow hematopoiesis or anemia, leukopenia, thrombocytopenia due to other causes (other than rheumatoid arthritis);

- Infection heavy flow;

- Moderate or severe renal insufficiency (because of the small experience of clinical observations);

- Severe hypoproteinemia (including with nephrotic syndrome);

- Pregnancy;

- Lactation (breastfeeding);

- Childhood and adolescence to 18 years;

- Hypersensitivity to the ingredients.

The drug is contraindicated in women of childbearing age who do not use adequate contraception.

Pregnancy and lactation

The drug should not be administered during pregnancy and women of childbearing age who are not using reliable contraception. You must verify the absence of pregnancy before starting treatment.

In experimental studies have found that the drug may have fetotoksicheskoe and teratogenic effect.

Patients should be informed that suspected pregnancy should seek medical advice immediately and do a pregnancy test. If the test is positive, the physician should inform the patient about the possible risk to the fetus.

Women who take leflunomide and want to become pregnant (or already in the ensuing pregnancy) procedure is recommended to launch the drug, which will rapidly reduce the concentration of leflunomide and its metabolite in blood plasma (after cessation of treatment prescribed leflunomide kolestiramin in a dose of 8 g 3 times / day within 11 days or 50 g of activated charcoal, crushed into powder, 4 times / day for 11 days).

Next, you need to determine the concentration of metabolite A771726 2 times with an interval of 14 days. From the moment when the concentration of the drug will be fixed below 20 mg / l until fertilization should take 1.5 months.

Note that without the procedure of removing the drug, reduced metabolite concentrations below 20 ug / l occurs in 2 years.

Kolestiramin and activated carbon can affect the absorption of estrogen and progesterone in such a way that reliable oral contraceptives do not guarantee the necessary contraception during launch preparation. It is recommended to use alternative methods of contraception.

Studies in animals have shown that leflunomide or its metabolites are excreted in breast milk milk. Therefore, the need to designate a lactation should resolve the issue of termination of breastfeeding.

There is currently no information confirming the link between taking the drug Arava men and fetotoksicheskim action of the drug. Experimental studies in this direction were made. However, men receiving leflunomide therapy, should be warned of the possible effect of fetotoksicheskom and the need to use adequate contraception. To minimize risk when planning pregnancy should stop taking leflunomide and use kolestiramin to 8 mg 3 times daily for 11 days or 50 grams of powdered activated charcoal 4 times daily for 11 days.

Cautions

Note that the drug Arava may be imposed only after a medical examination (including before starting treatment and during treatment should monitor blood pressure).

Before treatment drug Arava should be mindful of possible increase in the number of side effects in patients previously treated with other basic tools for the treatment of rheumatoid arthritis, which have hepato-and gematotoksicheskim action.

The active metabolite of leflunomide A771726 characterized by long T1 / 2. Therefore, side effects can occur even after cessation of therapy. If you have any similar cases of toxicity or when moving to another base receiving the drug after treatment with leflunomide should be the procedure of removing the drug (after the cessation of leflunomide treatment prescribed kolestiramin in a dose of 8 g 3 times daily for 11 days or 50 g of activated carbon, crushed to powder, 4 times / day for 11 days).

Note that during the development of severe dermatologic adverse reactions, severe infections receiving the drug Arava should stop and immediately initiate the removal of the drug.

Need to monitor patients with tuberculin reactivity due to the risk of activating tuberculosis.

Given the long-term elimination of Arava is not recommended to vaccinate live vaccines against a background of leflunomide treatment.

Overdose

No data on overdose of leflunomide. Admission leflunomide 100 mg daily for 14 days was observed in 10 healthy volunteers. Two of them were removed after a week because of the increased level of transaminases in the blood plasma.

In case of overdose or toxicity is recommended to use kolestiramina or powdered activated carbon. Kolestiramin, take 3 healthy volunteers administered orally to 8 mg 3 times / day during the day, reduced levels of A771726 in plasma by approximately 40% after 24 h and 49-65% after 48 h.

Shown that introduction of activated charcoal orally or via oral gavage (50 mg every 6 hours during the day) reduced the concentration of the active metabolite A771726 in plasma by 37% after 24 h and 48% after 48 h.

Perhaps repetition procedures are preparation for clinical indications.

Drug Interactions

Increased adverse reactions may occur in the case of recent or concomitant use of hepatotoxic drugs or hematotoxicity or when receiving these drugs after starting leflunomide treatment procedure without removing the drug.

Not observed pharmacokinetic interaction between leflunomide (10-20 mg / day) and methotrexate (10-25 mg / week).

Unknown clinically significant interactions with concomitant use of leflunomide and triphasic oral contraceptives, NSAIDs, cimetidine, rifampicin.

Studies in vitro showed that the metabolite of leflunomide A771726 inhibits the activity of cytochrome P450 2C9. Therefore, caution should be prescribed the drug Arava with drugs metabolized by this enzyme system (phenytoin, warfarin, tolbutamide).


Conditions and terms of storage

The product should be stored at temperatures not above 25 ° C. Shelf life – 3 years.

Conditions of supply of pharmacies

The drug is released with a prescription.

BUY ARAVA cheap

Latin name
Cozaar ®
ATC:
>> C09CA01 Losartan
Pharmacological Group
>> Receptor antagonists of angiotensin II (AT1-subtype)
Nosological classification (ICD-10)
>> I10-I15 Diseases characterized by high blood pressure
>> I50 Heart failure
The composition and the form
1 tablet contains losartan potassium 12.5 or 50 mg in the contour of cellular packing 21 or 14 pieces., In box 2 and 1 pack respectively.
Pharmacological action
Mode of action – hypotensive. Blocks angiotensin II (type AT1) reduces OPSS, reduces afterload, reduces systemic blood pressure and the pressure in the lesser circulation.
Pharmacokinetics
Well absorbed. Be distributed relatively evenly. Metabolized to form the active derivative.
Pharmacodynamics
Maximum antihypertensive effect is achieved within 3-6 weeks of treatment.
Indications
Arterial hypertension, heart failure (including when treatment with ACE inhibitors is no longer appropriate for the patient.
Contraindications
Hypersensitivity, children’s age.
Application of pregnancy and breastfeeding
When the reception immediately terminate pregnancy (may cause developmental defects or fetal death, especially in the II-III trimester). Nursing mothers should stop breastfeeding.
Side effects
Dizziness, hypotension (dose-related), hyperkalemia (1.5% of patients).
Interaction
Compatible with other antihypertensive agents. Against the background of diuretics (high doses) increases the risk of excessive hypotension in patients with dehydration.
Overdose
The most likely manifestation – hypotension and tachycardia (possible vagal bradycardia). Treatment of symptomatic – no Kozaar nor its active metabolite are not displayed hemodialysis.
Dosing and Administration
Inside, regardless of the meal, once. Usually – 50 mg / day. In some cases, to achieve greater effect, increase the dose to 100 mg. Patients with dehydration may make an initial dose of 25 mg / day. For patients with heart failure the initial dose may reach 12.5 mg 1 time per day.
Precautions
Patients with a history of liver disease should be prescribed lower doses (plasma concentration significantly increased for violations of its functions, especially with cirrhosis).
Expiration
3 years
Storage
List B.: In the dark place at a temperature not above 25 ° C.
Date update
2001-07-31

Latin name

Cozaar ®

ATC:

>> C09CA01 Losartan

Pharmacological Group

>> Receptor antagonists of angiotensin II (AT1-subtype)

Nosological classification (ICD-10)

>> I10-I15 Diseases characterized by high blood pressure

>> I50 Heart failure

The composition and the form

1 tablet contains losartan potassium 12.5 or 50 mg in the contour of cellular packing 21 or 14 pieces., In box 2 and 1 pack respectively.

Pharmacological action

Mode of action – hypotensive. Blocks angiotensin II (type AT1) reduces OPSS, reduces afterload, reduces systemic blood pressure and the pressure in the lesser circulation.

Pharmacokinetics

Well absorbed. Be distributed relatively evenly. Metabolized to form the active derivative.

Pharmacodynamics

Maximum antihypertensive effect is achieved within 3-6 weeks of treatment.

Indications

Arterial hypertension, heart failure (including when treatment with ACE inhibitors is no longer appropriate for the patient.

Contraindications

Hypersensitivity, children’s age.

Application of pregnancy and breastfeeding

When the reception immediately terminate pregnancy (may cause developmental defects or fetal death, especially in the II-III trimester). Nursing mothers should stop breastfeeding.

Side effects

Dizziness, hypotension (dose-related), hyperkalemia (1.5% of patients).

Interaction

Compatible with other antihypertensive agents. Against the background of diuretics (high doses) increases the risk of excessive hypotension in patients with dehydration.

Overdose

The most likely manifestation – hypotension and tachycardia (possible vagal bradycardia). Treatment of symptomatic – no Kozaar nor its active metabolite are not displayed hemodialysis.

Dosing and Administration

Inside, regardless of the meal, once. Usually – 50 mg / day. In some cases, to achieve greater effect, increase the dose to 100 mg. Patients with dehydration may make an initial dose of 25 mg / day. For patients with heart failure the initial dose may reach 12.5 mg 1 time per day.

Precautions

Patients with a history of liver disease should be prescribed lower doses (plasma concentration significantly increased for violations of its functions, especially with cirrhosis).

Expiration

3 years

Storage

List B.: In the dark place at a temperature not above 25 ° C.

Date update

2001-07-31

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Coumadin – Warfarin
Coumadin should be taken strictly in accordance with a medical prescription.
If you are over 60 years, then as a rule, you should take a lower dose than is usually assigned to reduce the risk of bleeding
Taken once a day, preferably at the same time
After three months of the reception, your doctor should reassess the need to continue taking Coumadin.
In the case of misuse, Coumadin can cause serious side effects: haemorrhage, bleeding, bruises, red spots on the body, irritation and skin damage.
Precautions – protection against shock, falls, cuts – even insect bites can lead to hemorrhage.
Fractures, traumatic injuries, blows to the stomach – can lead to massive bleeding, blood loss and death, and therefore should take action and nemedlennopoluchit immediate medical attention!
During the reception Coumadin, your doctor should monitor your condition through regular blood PT / INR (Pi.Ti.) and change in dosage if necessary, to ensure maximum efficiency of treatment.
Coumadin interacts with virtually all drugs. Its anticoagulant effect is very difficult to control, if the period of his admission begins or ceases to use or change the dose of another drug. Another drug can amplify or weaken the effect of Coumadin.
During the reception Coumadin should not take any other medicines, including OTC drugs (eg aspirin, cold remedies, antacid, laxative), or change the dose, which you are currently taking, without first talking to your doctor.
Note the interaction with Coumadin Paracetamol (Akamol-Deksamol) – the risk of bleeding increases tenfold!
Talk to your doctor, how to behave in case of need anesthesia.
Analysis – PT / INR as balancing performance and prescribed by the doctor once every 3 months: hemoglobin, platelet count, liver function tests, albumin, liver enzymes, kidney parameters, bleeding time, tests of functional activity of platelets
Take Coumadin dose should agree with the doctor, depending on the result of the analysis of PT / INR.
Do not take the responsibility for the appointment dose lekarstva.Tolko doctor can and knows how to take and will give you a diagram.
It is important to draw attention to the fact that interaction coumadin vegetables green.
Since Coumadin interacts with vitamin K, while taking Coumadin prohibited use food white cabbage (even fermented), red, color, Brussels sprouts, broccoli, cilantro, parsley, celery, fennel (green), lettuce, green onions, green peas, green beans, avocado

Coumadin – Warfarin

Coumadin should be taken strictly in accordance with a medical prescription.


If you are over 60 years, then as a rule, you should take a lower dose than is usually assigned to reduce the risk of bleeding


Taken once a day, preferably at the same time


After three months of the reception, your doctor should reassess the need to continue taking Coumadin.


In the case of misuse, Coumadin can cause serious side effects: haemorrhage, bleeding, bruises, red spots on the body, irritation and skin damage.


Precautions – protection against shock, falls, cuts – even insect bites can lead to hemorrhage.

Fractures, traumatic injuries, blows to the stomach – can lead to massive bleeding, blood loss and death, and therefore should take action and nemedlennopoluchit immediate medical attention!


During the reception Coumadin, your doctor should monitor your condition through regular blood PT / INR (Pi.Ti.) and change in dosage if necessary, to ensure maximum efficiency of treatment.


Coumadin interacts with virtually all drugs. Its anticoagulant effect is very difficult to control, if the period of his admission begins or ceases to use or change the dose of another drug. Another drug can amplify or weaken the effect of Coumadin.


During the reception Coumadin should not take any other medicines, including OTC drugs (eg aspirin, cold remedies, antacid, laxative), or change the dose, which you are currently taking, without first talking to your doctor.

Note the interaction with Coumadin Paracetamol (Akamol-Deksamol) – the risk of bleeding increases tenfold!


Talk to your doctor, how to behave in case of need anesthesia.


Analysis – PT / INR as balancing performance and prescribed by the doctor once every 3 months: hemoglobin, platelet count, liver function tests, albumin, liver enzymes, kidney parameters, bleeding time, tests of functional activity of platelets


Take Coumadin dose should agree with the doctor, depending on the result of the analysis of PT / INR.

Do not take the responsibility for the appointment dose lekarstva.Tolko doctor can and knows how to take and will give you a diagram.


It is important to draw attention to the fact that interaction coumadin vegetables green.


Since Coumadin interacts with vitamin K, while taking Coumadin prohibited use food white cabbage (even fermented), red, color, Brussels sprouts, broccoli, cilantro, parsley, celery, fennel (green), lettuce, green onions, green peas, green beans, avocado.

buy Coumadin

Name: Amara (Amaryl)
Pharmacological Effects:
Amari – preparation sulfonylureas, oral hypoglycemic agent. Has primary prolonged effect. The mechanism of action is to stimulate the secretion and release of insulin from beta cells of the pancreas (pancreatic effect). Also increases the sensitivity of fat and muscle tissue to insulin (ekstrapankreatichesky effect). It acts by blocking the cytoplasmic ATP-dependent potassium channel beta-cells of the pancreas. This is accompanied by the opening of calcium channel beta-cell membranes and increase the infiltration of calcium (depolarization).
Active ingredient amara – glimepiride – quick disconnects and connects with the beta-cell proteins, which has a molecular mass of 65 kDa / SURX and is associated with adenosine triphosphoric-dependent potassium channels. From other sulfonylurea derivatives differs in that there is no interaction with the protein beta-cells with a molecular mass of 140 kD/SUR1. This leads to the exocytosis of insulin, and the content of released insulin is much less than the influence of other traditional medicines. Slight amara stimulating effect on the secretion of beta-cells, insulin leads to a lower risk of hypoglycemia.
Amara Ekstrapankreatichesky effect leads to a decrease in insulin resistance, a negligible impact on the cardiovascular system. Has antiagregantnym, antiatherogenic and antioxidant effects.
Increased glucose utilization of fat and muscle tissue is carried out due to the presence in cell membranes of specific transport proteins. With the penetration of glucose-insulin-dependent diabetes in these tissues is restricted at the stage of disposal. Amari rapidly increases the activity of transport proteins, through which glucose is absorbed better. There is also an increase in the number of transport proteins on the background of Amarah. Virtually no blocking effects on ATP-dependent potassium channels of cardiac myocytes. Saved on the possibility of metabolic adaptation of cardiomyocytes to ischemic conditions. Increases the activity of specific glikozil-phosphatidylinositol-phospholipase C, which accounts for observed correlated with the admission amara glikogenez and lipogenesis.
Amari blocking hepatic production of glucose by increasing the content in hepatocytes of fructose-2 ,6-bisfosfata (the latter also inhibits gluconeogenesis).
Against the background of the drug observed blocking secretion of COX and a decrease in the transformation of arachidonic acid to thromboxane A2, thereby decreasing platelet aggregation (antithrombotic effect). Influenced amara observed increase in the concentration of alpha-tocopherol, which is produced endogenously. Also there is increased activity of superoxide dismutase, catalase and glyutationperoksidazy that manifested reduced severity of oxidative reactions in diabetes mellitus.
Indications:
Insulin-dependent diabetes mellitus (type 2) – as monotherapy or in combination with insulin (or metformin).
Dosing:
Amari are inside. Tablets do not chew,? High water about 150 ml. It is important not to forget to eat after dosing.
Starting and maintenance dosage is established physician individually depending on the level of glucose in the blood serum and its excretion in the urine.
First, apply the medication to 1 mg / day, if necessary, you can gradually increase the daily dose of 6 mg. Dose escalation is carried out at intervals of 1-2 weeks according to the scheme: 1 mg/sutki-2 mg/sutki-3 mg/sutki-4 mg/sutki-6 mg / day Amarah. Not exceed the recommended dose amara more than 6 mg / day. Multiplicity and time consumption of the drug is determined by the individual physician, depending on the lifestyle of the patient. Typically, the daily dose prescribed amara 1 time per day during or before the first plentiful meal (breakfast). If the morning dose was not adopted – that during or before the second meal. Prolonged therapy.
Using a combination of Amar metformin. Those patients who are taking metformin, and they have observed the lack of decrease of glucose in the blood serum, you can start receiving additional Amarah. If the daily dosage of metformin does not change, then the therapy Amarillo begin with a dose of 1 mg / day. Subsequently amara dose can be increased to achieve the desired reduction of glucose in the blood serum up to 6 mg / day.
Using a combination of Amar insulin. To stabilize the glucose in the blood serum in cases where the use of monotherapy or combination Amar metformin inefficiently used a combination of insulin with Amarillo. This dose amara left unchanged, but insulin therapy starting with small doses. In the future, may increase insulin. Therapy should be accompanied by monitoring the concentration of glucose in the blood serum. The treatment is performed under the supervision of the treating physician. Scheme insulin-Amari can reduce the need for insulin by about 40%.
Replacing another antidiabetes therapies Amara. Launch treated with 1 mg / day Amarah, in not depending on the dose of previous medication (even if it was maximal). Depending on the therapeutic effect amara can increase the dose of the above rules. In some instances, removal of Amari because of the risk of hypoglycemia (especially if the Amari to use the drug with a high value of the half-life – hlorpropramid). Therapy is stopped for a few days (because of the probable additive effect).
Replacement of insulin in Amarah. In cases where patients with type 2 diabetes insulin is prescribed, but they remained intact insulinsekretiruyuschaya function of beta cells of the pancreas, can be translated to the patient an appointment with amara except insulin. In this case, therapy Amarillo begin with a dose of 1 mg / day.
Side effects:
Metabolism: The Rise of hypoglycemic reactions shortly after receiving Amari (such reactions are very difficult to correct).
Nervous system: headache, sleep disturbances, drowsiness, fatigue, aggressiveness, anxiety, changes in concentration and velocity of the psycho-motor responses, visual and speech disturbances, dizziness, confusion, depression, sensory disturbances, aphasia, disturbances of coordination, paresis, helpless condition, cerebral convulsions, loss of self-control, tremor, loss or confusion, delirium, coma, restlessness, cold, clammy sweat.
Gastrointestinal tract: vomiting, epigastric discomfort, hunger, abdominal pain, diarrhea, jaundice, cholestasis, elevation of liver transaminases, hepatitis, liver failure, nausea.
Cardiovascular system: tachycardia, cardiac arrhythmia, hypertension, bradycardia, angina pectoris.
Organ of: transient visual disturbances due to changes in blood glucose (especially in the beginning of therapy).
The respiratory system: shallow breathing.
Hematopoietic system: leucopenia, thrombocytopenia (moderate or severe), erythropenia, aplastic or hemolytic anemia, granulocytopenia, pancytopenia, agranulocytosis.
Hypersensitivity reactions: urticaria, itching, skin rashes, allergic vasculitis. Allergic reactions are usually slightly expressed, but it is sometimes possible progression up to anaphylactic shock. Perhaps cross-reaction to sulfonylureas, as well as sulfanilamidami.
Other: hyponatremia, photosensitivity.
Contraindications:
• genesis of diabetic ketoacidosis, diabetic coma and prekoma,
• insulin-dependent diabetes mellitus (type 1),
• Expression of renal dysfunction (including patients on hemodialysis),
• severe hepatic impairment,
• Individual hypersensitivity to Amarillo (Glimepiride) or other components of the drug, other means sulfonylureas, sulfonamides.
Pregnancy:
Amari should not be administered to pregnant women and women breast-feeding. If the patient is planning a pregnancy, it must be translated into the introduction of insulin with the exception of Amarah. If the patient is breastfeeding, she continued to insulin or breast-feeding stopped (because Amari passes into breast milk).
Interaction with other drugs:
In combination with insulin, other medication for the treatment of hypoglycemia, allopurinol, inhibitors of angiotensin-converting factor, male sex hormones, anabolic steroids, coumarin derivatives, chloramphenicol, fenfluramine, fluoxetine, fibrates, feniramidolom, MAO inhibitors, guanetidinom, pentoxifylline (with the introduction parenterally in large doses ), miconazole, azapropazonom, phenylbutazone, quinolones, probenecid, oksifenbutazonom, salicylates, sulfinpirazonom, tetracyclines, sulfonamides of prolonged action, tritokvalinom, Tropics, cyclo-, and ifosfamide may increase hypoglycemic effect of Amarah.
In combination with adrenaline (epinephrine) and sympathomimetics, acetazolamide, glucocorticosteroid, glucagon, diazoksidom, barbiturates, saluretics laxatives (prolonged use), thiazide diuretics, nicotinic acid in large doses, phenytoin, phenothiazines, rifampin, progestogens and estrogens, chlorpromazine , thyroid hormone, lithium salts may decrease hypoglycemic effect of Amarah.
In combination with amara reserpine, clonidine and blocking histamine H2-receptors may decrease as well as increased hypoglycemic effect.
May decrease or weakening of the effects of coumarin and its derivatives in conjunction with Amarillo. Prolonged or single use entanolsoderzhaschih drugs and drinks can both weaken and strengthen the hypoglycemic effect of Amarah.
Overdose:
In case of overdose amara possible hypoglycemia within 12-72 hours of admission amara in the high dose. Perhaps the re-development of hypoglycemia after the restoration of glucose in the blood. Hypoglycemia manifested by the following symptoms: high blood pressure, increased sweating, nausea, vomiting, arrhythmia, pain in the heart, anxiety, rapid increase of appetite, lethargy, dizziness, drowsiness, headache, anxiety, palpitations, aggression, violation of concentration, tremor , confusion, paresis, depression, breach of sensitivity, tachycardia, seizures of central origin. In some cases, hypoglycemia is manifested symptoms of stroke. There is a risk of coma. Treatment of hypoglycemia should begin with taking a piece of sugar, sweet tea or juice. The patient was warned that he always had with him approximately 20 g of glucose (in the form of 4 pieces of sugar, for example). In the treatment ineffective are the various sweeteners. In severe cases require hospitalization. By induction of vomiting, the patient spend dehydration (water with activated charcoal inside a laxative). Parenteral dextrose injected (intravenous bolus 40% solution 50 ml). In the future, use diluted dextrose (10% solution). Treatment was escorted to the constant control of glucose in the blood serum. Other indications cropped symptomatic treatment.
In case of accidental admission amara people without diabetes (children) need to avoid the development of hyperglycemia. A dose of dextrose carefully selected on the background monitoring of glucose in the blood serum.
Product:
Amari – tablets are dividing strip, elongated shape. Glimepiride Tablets 1 ml have a pink color. Amari, 2 ml – tablets green. Amari and 3 mg – Tablets light yellow color. Amari to 4 mg – green. In package 2 blisters, each with 15 tablets.
Storage:
Amari is stored at a temperature not exceeding 25 ° C. Shelf life – 3 years.
Ingredients:
Active ingredient: Glimepiride.
Inactive components: lactose monohydrate, polyvidone 25 000, sodium starch glycolate, microcrystalline cellulose, magnesium stearate, dyes (for amara 1 mg – iron oxide red (E172), for amara 2 mg – iron oxide yellow (E172) and indigo (E132) for amara 3 mg – iron oxide yellow (E172), for amara 4 mg – indigo (E132).
Extras:
In the treatment of Amarillo need to remember the states that require the transfer of the patient on parenteral administration of insulin (polytrauma, surgery, illness with fever, extensive burns, modified food absorption from the gastrointestinal tract in diseases – intestinal obstruction, intestinal paresis, etc.) .
In combination Amar metformin should be borne in mind that taking high doses of metformin and glimepiride sovrovozhdaetsya marked improvement in metabolism in patients with uncontrolled diabetes type. In the case of high doses of metformin and Amara, if the control still inadequate, it is possible to transfer the patient to a combination of Amar insulin.
Factors that encourage the development of hypoglycemia: low komplaentnost patient, inadequate, irregular meals, habitual diet changes, omissions, eating, drinking, fasting, changing the balance between carbohydrate intake and physical activity, severe dysfunction of the liver and kidneys; related uncompensated endocrine diseases , an overdose of Amara, thyroid gland, adrenal insufficiency, pituitary insufficiency, the combination with other drugs.
Signs of hypoglycemia are offset in the elderly, patients with neurocirculatory dystonia, patients who take beta-blockers, reserpine, clonidine, guanetidin, simpatolitiki.
Dose is adjusted individually depending on the content of glucose in the blood. If another dose is missed, absolutely not supposed to accept the next higher dose. Patient should inform your doctor about receiving too high doses of Amarah. In the case of compensation of diabetes may begin to improve sensitivity to insulin, thus possibly reducing the dose Amari (or even cancellation of the drug). Need to adjust the dose amara the appearance of various factors that may provoke hypoglycemia or hyperglycemia, as well as in the case of change of lifestyle. It must be remembered that the right diet, correction of physical activity, weight loss are of great importance for the treatment of diabetes while taking Amarah.
Should inform the patient that he immediately informed the doctor all the side effects that develop on a background therapy of Amarillo. It is also necessary to inform him about the factors that cause both hyper-and hypoglycemia and the symptoms of these conditions.
Therapy of Amarillo should be accompanied by regular monitoring of glucose in the blood serum, urine, determination of glycated hemoglobin concentration. Regular monitoring of these laboratory parameters in time helps to identify possible resistance to the drug of primary or secondary nature.
In the laboratory control includes the determination of liver function, complete blood count. Against the background of drug therapy may decrease the rate of psycho-motor reactions, and therefore work with the precise mechanisms and driving contraindicated. Especially concerns the initial stages of treatment Amarillo.
Warning
Before using the product Amari, you should consult your doctor. This instruction is given a free transfer and is intended solely for review. For more information, please contact the manufacturer annotations.

Name: Amara (Amaryl)

Pharmacological Effects:

Amari – preparation sulfonylureas, oral hypoglycemic agent. Has primary prolonged effect. The mechanism of action is to stimulate the secretion and release of insulin from beta cells of the pancreas (pancreatic effect). Also increases the sensitivity of fat and muscle tissue to insulin (ekstrapankreatichesky effect). It acts by blocking the cytoplasmic ATP-dependent potassium channel beta-cells of the pancreas. This is accompanied by the opening of calcium channel beta-cell membranes and increase the infiltration of calcium (depolarization).

Active ingredient amara – glimepiride – quick disconnects and connects with the beta-cell proteins, which has a molecular mass of 65 kDa / SURX and is associated with adenosine triphosphoric-dependent potassium channels. From other sulfonylurea derivatives differs in that there is no interaction with the protein beta-cells with a molecular mass of 140 kD/SUR1. This leads to the exocytosis of insulin, and the content of released insulin is much less than the influence of other traditional medicines. Slight amara stimulating effect on the secretion of beta-cells, insulin leads to a lower risk of hypoglycemia.

Amara Ekstrapankreatichesky effect leads to a decrease in insulin resistance, a negligible impact on the cardiovascular system. Has antiagregantnym, antiatherogenic and antioxidant effects.

Increased glucose utilization of fat and muscle tissue is carried out due to the presence in cell membranes of specific transport proteins. With the penetration of glucose-insulin-dependent diabetes in these tissues is restricted at the stage of disposal. Amari rapidly increases the activity of transport proteins, through which glucose is absorbed better. There is also an increase in the number of transport proteins on the background of Amarah. Virtually no blocking effects on ATP-dependent potassium channels of cardiac myocytes. Saved on the possibility of metabolic adaptation of cardiomyocytes to ischemic conditions. Increases the activity of specific glikozil-phosphatidylinositol-phospholipase C, which accounts for observed correlated with the admission amara glikogenez and lipogenesis.

Amari blocking hepatic production of glucose by increasing the content in hepatocytes of fructose-2 ,6-bisfosfata (the latter also inhibits gluconeogenesis).

Against the background of the drug observed blocking secretion of COX and a decrease in the transformation of arachidonic acid to thromboxane A2, thereby decreasing platelet aggregation (antithrombotic effect). Influenced amara observed increase in the concentration of alpha-tocopherol, which is produced endogenously. Also there is increased activity of superoxide dismutase, catalase and glyutationperoksidazy that manifested reduced severity of oxidative reactions in diabetes mellitus.

Indications:

Insulin-dependent diabetes mellitus (type 2) – as monotherapy or in combination with insulin (or metformin).

Dosing:

Amari are inside. Tablets do not chew,? High water about 150 ml. It is important not to forget to eat after dosing.

Starting and maintenance dosage is established physician individually depending on the level of glucose in the blood serum and its excretion in the urine.

First, apply the medication to 1 mg / day, if necessary, you can gradually increase the daily dose of 6 mg. Dose escalation is carried out at intervals of 1-2 weeks according to the scheme: 1 mg/sutki-2 mg/sutki-3 mg/sutki-4 mg/sutki-6 mg / day Amarah. Not exceed the recommended dose amara more than 6 mg / day. Multiplicity and time consumption of the drug is determined by the individual physician, depending on the lifestyle of the patient. Typically, the daily dose prescribed amara 1 time per day during or before the first plentiful meal (breakfast). If the morning dose was not adopted – that during or before the second meal. Prolonged therapy.

Using a combination of Amar metformin. Those patients who are taking metformin, and they have observed the lack of decrease of glucose in the blood serum, you can start receiving additional Amarah. If the daily dosage of metformin does not change, then the therapy Amarillo begin with a dose of 1 mg / day. Subsequently amara dose can be increased to achieve the desired reduction of glucose in the blood serum up to 6 mg / day.

Using a combination of Amar insulin. To stabilize the glucose in the blood serum in cases where the use of monotherapy or combination Amar metformin inefficiently used a combination of insulin with Amarillo. This dose amara left unchanged, but insulin therapy starting with small doses. In the future, may increase insulin. Therapy should be accompanied by monitoring the concentration of glucose in the blood serum. The treatment is performed under the supervision of the treating physician. Scheme insulin-Amari can reduce the need for insulin by about 40%.

Replacing another antidiabetes therapies Amara. Launch treated with 1 mg / day Amarah, in not depending on the dose of previous medication (even if it was maximal). Depending on the therapeutic effect amara can increase the dose of the above rules. In some instances, removal of Amari because of the risk of hypoglycemia (especially if the Amari to use the drug with a high value of the half-life – hlorpropramid). Therapy is stopped for a few days (because of the probable additive effect).

Replacement of insulin in Amarah. In cases where patients with type 2 diabetes insulin is prescribed, but they remained intact insulinsekretiruyuschaya function of beta cells of the pancreas, can be translated to the patient an appointment with amara except insulin. In this case, therapy Amarillo begin with a dose of 1 mg / day.

Side effects:

Metabolism: The Rise of hypoglycemic reactions shortly after receiving Amari (such reactions are very difficult to correct).

Nervous system: headache, sleep disturbances, drowsiness, fatigue, aggressiveness, anxiety, changes in concentration and velocity of the psycho-motor responses, visual and speech disturbances, dizziness, confusion, depression, sensory disturbances, aphasia, disturbances of coordination, paresis, helpless condition, cerebral convulsions, loss of self-control, tremor, loss or confusion, delirium, coma, restlessness, cold, clammy sweat.

Gastrointestinal tract: vomiting, epigastric discomfort, hunger, abdominal pain, diarrhea, jaundice, cholestasis, elevation of liver transaminases, hepatitis, liver failure, nausea.

Cardiovascular system: tachycardia, cardiac arrhythmia, hypertension, bradycardia, angina pectoris.

Organ of: transient visual disturbances due to changes in blood glucose (especially in the beginning of therapy).

The respiratory system: shallow breathing.

Hematopoietic system: leucopenia, thrombocytopenia (moderate or severe), erythropenia, aplastic or hemolytic anemia, granulocytopenia, pancytopenia, agranulocytosis.

Hypersensitivity reactions: urticaria, itching, skin rashes, allergic vasculitis. Allergic reactions are usually slightly expressed, but it is sometimes possible progression up to anaphylactic shock. Perhaps cross-reaction to sulfonylureas, as well as sulfanilamidami.

Other: hyponatremia, photosensitivity.

Contraindications:

• genesis of diabetic ketoacidosis, diabetic coma and prekoma,

• insulin-dependent diabetes mellitus (type 1),

• Expression of renal dysfunction (including patients on hemodialysis),

• severe hepatic impairment,

• Individual hypersensitivity to Amarillo (Glimepiride) or other components of the drug, other means sulfonylureas, sulfonamides.

Pregnancy:

Amari should not be administered to pregnant women and women breast-feeding. If the patient is planning a pregnancy, it must be translated into the introduction of insulin with the exception of Amarah. If the patient is breastfeeding, she continued to insulin or breast-feeding stopped (because Amari passes into breast milk).

Interaction with other drugs:

In combination with insulin, other medication for the treatment of hypoglycemia, allopurinol, inhibitors of angiotensin-converting factor, male sex hormones, anabolic steroids, coumarin derivatives, chloramphenicol, fenfluramine, fluoxetine, fibrates, feniramidolom, MAO inhibitors, guanetidinom, pentoxifylline (with the introduction parenterally in large doses ), miconazole, azapropazonom, phenylbutazone, quinolones, probenecid, oksifenbutazonom, salicylates, sulfinpirazonom, tetracyclines, sulfonamides of prolonged action, tritokvalinom, Tropics, cyclo-, and ifosfamide may increase hypoglycemic effect of Amarah.

In combination with adrenaline (epinephrine) and sympathomimetics, acetazolamide, glucocorticosteroid, glucagon, diazoksidom, barbiturates, saluretics laxatives (prolonged use), thiazide diuretics, nicotinic acid in large doses, phenytoin, phenothiazines, rifampin, progestogens and estrogens, chlorpromazine , thyroid hormone, lithium salts may decrease hypoglycemic effect of Amarah.

In combination with amara reserpine, clonidine and blocking histamine H2-receptors may decrease as well as increased hypoglycemic effect.

May decrease or weakening of the effects of coumarin and its derivatives in conjunction with Amarillo. Prolonged or single use entanolsoderzhaschih drugs and drinks can both weaken and strengthen the hypoglycemic effect of Amarah.

Overdose:

In case of overdose amara possible hypoglycemia within 12-72 hours of admission amara in the high dose. Perhaps the re-development of hypoglycemia after the restoration of glucose in the blood. Hypoglycemia manifested by the following symptoms: high blood pressure, increased sweating, nausea, vomiting, arrhythmia, pain in the heart, anxiety, rapid increase of appetite, lethargy, dizziness, drowsiness, headache, anxiety, palpitations, aggression, violation of concentration, tremor , confusion, paresis, depression, breach of sensitivity, tachycardia, seizures of central origin. In some cases, hypoglycemia is manifested symptoms of stroke. There is a risk of coma. Treatment of hypoglycemia should begin with taking a piece of sugar, sweet tea or juice. The patient was warned that he always had with him approximately 20 g of glucose (in the form of 4 pieces of sugar, for example). In the treatment ineffective are the various sweeteners. In severe cases require hospitalization. By induction of vomiting, the patient spend dehydration (water with activated charcoal inside a laxative). Parenteral dextrose injected (intravenous bolus 40% solution 50 ml). In the future, use diluted dextrose (10% solution). Treatment was escorted to the constant control of glucose in the blood serum. Other indications cropped symptomatic treatment.

In case of accidental admission amara people without diabetes (children) need to avoid the development of hyperglycemia. A dose of dextrose carefully selected on the background monitoring of glucose in the blood serum.

Product:

Amari – tablets are dividing strip, elongated shape. Glimepiride Tablets 1 ml have a pink color. Amari, 2 ml – tablets green. Amari and 3 mg – Tablets light yellow color. Amari to 4 mg – green. In package 2 blisters, each with 15 tablets.

Storage:

Amari is stored at a temperature not exceeding 25 ° C. Shelf life – 3 years.

Ingredients:

Active ingredient: Glimepiride.

Inactive components: lactose monohydrate, polyvidone 25 000, sodium starch glycolate, microcrystalline cellulose, magnesium stearate, dyes (for amara 1 mg – iron oxide red (E172), for amara 2 mg – iron oxide yellow (E172) and indigo (E132) for amara 3 mg – iron oxide yellow (E172), for amara 4 mg – indigo (E132).

Extras:

In the treatment of Amarillo need to remember the states that require the transfer of the patient on parenteral administration of insulin (polytrauma, surgery, illness with fever, extensive burns, modified food absorption from the gastrointestinal tract in diseases – intestinal obstruction, intestinal paresis, etc.) .

In combination Amar metformin should be borne in mind that taking high doses of metformin and glimepiride sovrovozhdaetsya marked improvement in metabolism in patients with uncontrolled diabetes type. In the case of high doses of metformin and Amara, if the control still inadequate, it is possible to transfer the patient to a combination of Amar insulin.

Factors that encourage the development of hypoglycemia: low komplaentnost patient, inadequate, irregular meals, habitual diet changes, omissions, eating, drinking, fasting, changing the balance between carbohydrate intake and physical activity, severe dysfunction of the liver and kidneys; related uncompensated endocrine diseases , an overdose of Amara, thyroid gland, adrenal insufficiency, pituitary insufficiency, the combination with other drugs.

Signs of hypoglycemia are offset in the elderly, patients with neurocirculatory dystonia, patients who take beta-blockers, reserpine, clonidine, guanetidin, simpatolitiki.

Dose is adjusted individually depending on the content of glucose in the blood. If another dose is missed, absolutely not supposed to accept the next higher dose. Patient should inform your doctor about receiving too high doses of Amarah. In the case of compensation of diabetes may begin to improve sensitivity to insulin, thus possibly reducing the dose Amari (or even cancellation of the drug). Need to adjust the dose amara the appearance of various factors that may provoke hypoglycemia or hyperglycemia, as well as in the case of change of lifestyle. It must be remembered that the right diet, correction of physical activity, weight loss are of great importance for the treatment of diabetes while taking Amarah.

Should inform the patient that he immediately informed the doctor all the side effects that develop on a background therapy of Amarillo. It is also necessary to inform him about the factors that cause both hyper-and hypoglycemia and the symptoms of these conditions.

Therapy of Amarillo should be accompanied by regular monitoring of glucose in the blood serum, urine, determination of glycated hemoglobin concentration. Regular monitoring of these laboratory parameters in time helps to identify possible resistance to the drug of primary or secondary nature.

In the laboratory control includes the determination of liver function, complete blood count. Against the background of drug therapy may decrease the rate of psycho-motor reactions, and therefore work with the precise mechanisms and driving contraindicated. Especially concerns the initial stages of treatment Amarillo.

Amaryl. Best price. OFFERS

Warning

Before using the product Amari, you should consult your doctor. This instruction is given a free transfer and is intended solely for review. For more information, please contact the manufacturer annotations.

Latin name
Adalat ®
ATC:
>> C08CA05 Nifedipine
Pharmacological Group
>> Calcium channel blockers
The composition and the form
Solution for infusion 1 fl. (50 ml)
Nifedipine 5 mg
Excipients: ethanol 96%, macrogol 400, sodium hydroxide, 0,1 N.; water for injection
in dark glass vials of 50 ml (complete with a syringe, tube PE) in the stack of cardboard 1 set.
Pharmacological action
Mode of action – antianginalnoe, hypotensive.
Dosing and Administration
In / in, infusion, within approximately 4-8 h (at a rate 6,3-12,5 ml / h, which corresponds to 0,63-1,25 mg / h nifedipine).
Maximum dose, administered within 24 hours should not exceed 150-300 ml (equivalent to 15-30 mg / day nifedipine).
In patients with renal impairment dose adjustment is required.
Infusion therapy may be performed continuously for 3 days. Then recommended the transition to oral therapy nifedipine.
Instructions for the introduction of the solution for infusion Adalat ®
Ready-to-use infusion solution Adalat ® should be administered only through a special syringe and vascular system marks perfusors ® or Inzhektomat ®, annexed to the solution. Subject to the use of prescribed infusion supplies loss nifedipine through conducting system can not be afraid.
Nifedipine (active substance infusion solution Adalat ®) is sensitive to light, so it is necessary to protect the solution from this impact.
Equipped with the protective plastic shell vial must be removed from packaging only immediately before use.
When the hybrid infusion must also provide protection solution Adalat ® from exposure to light, so it has to be entered directly into the infusion tube, which has already received a different solution, with the introduction of the system should be implemented as close as possible to the site of vein puncture. It is strictly forbidden to mix the solution Adalat ® in a vial with other solutions.
If the solution was kept in the refrigerator, before the introduction of its temperature must be brought to room temperature.

Latin name

Adalat ®

ATC:

>> C08CA05 Nifedipine

Pharmacological Group

>> Calcium channel blockers

The composition and the form

Solution for infusion 1 fl. (50 ml)

Nifedipine 5 mg

Excipients: ethanol 96%, macrogol 400, sodium hydroxide, 0,1 N.; water for injection

in dark glass vials of 50 ml (complete with a syringe, tube PE) in the stack of cardboard 1 set.

Pharmacological action

Mode of action – antianginalnoe, hypotensive.

Dosing and Administration

In / in, infusion, within approximately 4-8 h (at a rate 6,3-12,5 ml / h, which corresponds to 0,63-1,25 mg / h nifedipine).

Maximum dose, administered within 24 hours should not exceed 150-300 ml (equivalent to 15-30 mg / day nifedipine).

In patients with renal impairment dose adjustment is required.

Infusion therapy may be performed continuously for 3 days. Then recommended the transition to oral therapy nifedipine.

Instructions for the introduction of the solution for infusion Adalat ®

Ready-to-use infusion solution Adalat ® should be administered only through a special syringe and vascular system marks perfusors ® or Inzhektomat ®, annexed to the solution. Subject to the use of prescribed infusion supplies loss nifedipine through conducting system can not be afraid.

Nifedipine (active substance infusion solution Adalat ®) is sensitive to light, so it is necessary to protect the solution from this impact.

Equipped with the protective plastic shell vial must be removed from packaging only immediately before use.

When the hybrid infusion must also provide protection solution Adalat ® from exposure to light, so it has to be entered directly into the infusion tube, which has already received a different solution, with the introduction of the system should be implemented as close as possible to the site of vein puncture. It is strictly forbidden to mix the solution Adalat ® in a vial with other solutions.

If the solution was kept in the refrigerator, before the introduction of its temperature must be brought to room temperature.

Adalat cheap

The composition of milk. General

• The composition of human milk is fully consistent with the needs of the rapidly growing body of the child and the most balanced;
• Milk individually on the composition of which is governed by the child, that is, the two mothers of the milk is different, besides changing during one feeding, as well as throughout the entire period of lactation;
• All nutrients are in optimal form for absorption. No, even the best mix, is not a full substitute for breast milk.
In addition to the child’s optimal balance of fats, proteins and carbohydrates in breast milk contains substances that contribute to its digestion (autofermenty), the body immune to various kinds of diseases, the ideal composition of vitamins and enzymes.

Benefits of breastfeeding

The immediate benefits of breastfeeding
• reducing the risk of intestinal infections, prevention dysbacteriosis;
• reducing the risk of respiratory viral diseases such as otitis media;
• reducing the risk of allergic diseases (especially with hypoallergenic diet mother, in cases of predisposition to allergies of the child);
• Benefits of physical development of children;
• regulation of the biological age of maturation of children, slow biological maturation and, as a consequence, aging;
• advantages of neuro-psychological development of children, it may be more rapid, children are more active and emotionally and motor.
Remote advantages of breastfeeding
• neuro-psychological development, intelligence, social adaptation (breastfeeding contributes to a sense of self-confidence and sense of security, which in turn reduces the aggressiveness of an older age (relative to intelligence – there are studies by setting a higher level of IQ in children breastfed);
• reducing the risk of obesity and diabetes;
• Full reproductive function (especially for girls, reducing the probability of infertility and miscarriage);
• Formation of maxillo-facial skeleton, speech and hearing disorders (prevention of malocclusion, reducing the risk of speech and hearing disorders).
Benefits for Mom
• physical contact and emotional contact with the child, reducing the likelihood of neurosis;
• reducing the likelihood of cancer of breast and reproductive organs;
• Accelerating the size of uterine involution after delivery, reducing the risk of endometritis;
• normalization of cholesterol levels, reducing the risk of gall stone disease and osteoporosis;
• Cost savings and time;
• invaluable convenience for an active life with a child (food is always with them in the right quantity and the required temperature).

Dynamics of change in the composition of milk during lactation.

In the process of lactation is changing many biological properties and nutrients of milk. At maturity of the milk is divided into colostrum, transitional and mature milk.
Colostrum is a thick, sticky yellowish liquid that fills the breast during the last trimester of pregnancy. Appears immediately after birth and before the arrival of the transitional milk (usually within 1-3 days after birth). Provided in a very small quantity, which is enough for the child and does not overload his kidneys and digestive system. Has aperient effect to facilitate a discharge of meconium. The composition is like medicine.
Note: the introduction of water and lactation aid in the first days of life is a gross interference in the process of natural feeding and significantly reduces the effect of colostrum.
Transitional milk is approximately 4 to 13 days after birth. It may be accompanied by swelling of the mammary glands and a slight increase in body temperature. This process is also called the “rising tide”. Parish transitional milk comes in individual time after birth. Sometimes there is a delayed secretion of milk (galaktostaz) until 15-20 days after birth.
Mature milk usually appears by 15 day after birth.
In the literature on breastfeeding see the words “early” and “later milk. This terms are the evolution of the composition and properties of milk during one feeding from one breast.
Early (front) accumulates in breast milk between feedings and is produced in the early feeding. It has a bluish tint, can be transparent. Front milk is produced in large volume and meet the needs of the child not only in nutrients, but also to drink.
Later (back), milk produced at the end of lactation, after the front sucked milk. It is white, sometimes with a yellowish tinge. It is more dense, because it has more fat, which is the main source of energy when breastfeeding. Sucking back the milk, the child is making more effort.
In the breast milk of 87-90% water, so the child in the first 4-6 months does not need dopaivanii water even in hot climates.
Note: if a child receives more than milk and water, it will suck less milk, thereby reducing the number of the latter.

General rules for the organization full breastfeeding

1. A very important condition for the early establishment of lactation is the earlier the baby’s mother’s breast in the first 30 minutes – 2 hours after birth and lack of dogrudnogo feeding.
2. Correct the baby’s chest – a guarantee of effective sucking, lack of cracks and development of the required amount of milk.
3. Feeding on demand, rather than the regime. Must be at least 12 apposition day. Benefits of breastfeeding on demand: less problems with breast engorgement, the child gains weight more quickly, a rapid increase in the number of milk and increased yield, it is easier to form a child’s skills in breastfeeding.
4. Must night feeding. They are a condition of sufficient and long lactation, as well as produced the greatest amount of prolactin is at night in the interval from 3 to 8 in the morning.
5. The first 6 months of a child, who is to breastfeeding does not need feeding (juices, vegetable and fruit purees) and dopaivanii water.
6. With on-demand breast-feeding does not need pumping. Additional decantation may giperlaktatsii. Pumping is only justified in the following cases: post-partum engorgement, lactostasis, mastitis, insufficient lactation (on the recommendation of a specialist, such as a consultant on breastfeeding), with separation of a child with her mother.
7. The duration of breastfeeding. Do not limit your baby in nursing. Most of them are saturated for 10-20 minutes, but there are those who suck the breasts 30 minutes, 1 hour or more. Because the process of sucking for a child – not only food, but also communicate with her mother. The amount of time does not affect the formation of cracks and abrasions nipples. When the child ate and satisfied his interest in communicating with his mother, he releases the breast himself. “Lazy” and “nimble” sucker. Active sucker with a strong sucking reflex.
8. Alternating breasts. In one feeding given a chest. In case of insufficient lactation, and if the child is large and requires more, you can give both breasts per feeding. In this case, follow two basic rules:
• have the first chest child is at least 15-20 minutes. It should be possible to empty the breast (breast becomes soft, when pressing hardly stand a drop in white (rear) of milk);
• next feeding should begin with the breast, which was the last in the previous feeding.
9. In breastfeeding baby does not need a pacifier. The use of pacifiers – a habit my mother, which leads to nipple confusion, poor sucking, reduce the amount of milk. Dummy use is justified in the absence of my mother, if the child is over three months, subject to adequate breastfeeding and lack of problems by applying. If a child needs Fattened or drink (for medical reasons), the lactation aid and additional fluid should be given only from a spoon or a syringe or pipette. Do not use bottle nipples. This may lead to rejection of the breast. Note: In the early days of feeding can be a stomach ache – uterine contractions. When feeding from the second breast may leak milk. This effect of oxytocin, which will take place, when lactation is established. After feeding, the child can hold vertically or put on the mother’s abdomen to otrygnul air (may instead hiccup).

The main problems with breastfeeding

• cracked nipples, causes, care for the breast; means healing the crack.
• lack of milk (gipolaktatsiya) criteria for adequacy of milk; giperlaktatsiya.
• lactostasis; mastitis; causes, prevention, treatments.
• lactational crisis.

Cracks nipples. Motivations.

• poor latch. Typically, nipple cracks appear due to improper latch. It is therefore very important that the baby is already in the first lactation was attached properly. (see Appliances latch)
• Hypersensitivity skin nipples. There are situations when a baby is attached correctly, and my mother still there are cracks and abrasions. In this situation, we are talking about the high sensitivity of the skin nipples (usually, and the woman herself acknowledged that his chest and before the pregnancy was very sensitive).
• Confusion about the nipples. It occurs in children who suck a pacifier from birth or receiving Fattened bottle with a pacifier. Kid gets confused and tries to suck the breast as a pacifier, a pacifier, as the chest. And, if the nipple is still as it sucked, the chest – no: there are cracks, scratches, abrasions.
• Improper care of the breast. In Soviet times, all too often mums encouraged to wash your breasts with soap before and after feeding, handling breast Zelenkov and so on. Of course such a “caring” for breast led to injuries and to ensure that the baby refused the breast. Here’s why. At areola have special bumps – Montgomerovy glands that secrete a substance that protects the nipples. In addition, this substance seems to smell of amniotic fluid, which facilitates the task of finding the child breast and stimulates it to sucking. Now imagine that instead of Shishi, smelling of familiar and pleasant, kid gets something to the contrary – comes denial.
• Failure to correctly pick up the chest in the child.

Proper care for breast

• Do not wash your breasts with soap, do not smudge Zelenkov and so on. Suffice hygienic shower 1-2 times a day (without the use of soap and other means to care for the body).
• Express breast before feeding a few drops of colostrum / milk and lubricate the nipple, then the baby.
• After feeding, do the same and give the breast dry off in the air (air bath for 5-10 minutes) and only then, if necessary, apply an ointment or cream.
• Ensure that the area was dry nipples.
• Teach the child the right to seize the chest.
• Properly collect the chest in a child: the little finger (without manicure) to put in a child’s mouth in the course of the nipple and turn it between the gums. Kid gives his chest.
• Wear comfortable nursing bra made of natural fabrics. Adjust the straps so that the nipples were at the armpits.

Lack of milk. Hypogalactia. Nursing crisis.

Gipolaktatsiya or lack of milk. True or primary gipolaktatsiya extremely rare – only in 2-5% of women. A little more, we are seeing secondary gipolaktatsiyu, which happens because of improper organization of breastfeeding. And finally, most often the consultant is dealing with a false lack of milk.
Therefore, if you suspect a lack of milk, first of all, can not grasp at the bottle with the mixture, and must either alone or with the help of a specialist (a consultant on breastfeeding) to understand the situation. Usually, my mother, who complains about the lack of milk, the question “why do you think so?” Answers:
• crying more than you need;
• constantly “hangs” on the chest and sucks a long time during one feeding.
Test wet diapers. To eliminate the problem, you must first (before the panic, to run for a mixture therefore, etc.) to perform a test on the wet diaper. This is a very simple test, but very effective and, in contrast to the control of feeding (which offer a clinic) provides an objective assessment of the situation.
To do this, remove the baby diapers and count how many times the child write for days. Let’s start from birth. In the first three days is enough only 2-urination, the third to sixth – 4, starting with the sixth, there should be no less than 6 times a day. This lower boundary. There may be more, but based on the WHO until the 10 th day of life pipsqueak can easily exist without the lactation aid in compliance with such rules, and regardless of the weight loss (it is a full-term baby).
As soon as my mother’s milk has come, the number of urination increases strongly, their numbers are from 10 to 20 and more per day. If the results of “test for wet diapers” your baby pees more than 6-8 times per day, with the urine a pale yellow or transparent, and without pungent smell, then with the amount of milk you are all fine.
Weight Control. Immediately it should be noted that the control of weighing (weighing before and after feeding) nervous about the mother and child, resulting in a baby can do to stop gaining weight. Suffice it to watch an increase for 1 week, if you have a concern. If – no, one weighing in a month is enough. Last week, the child adds an average of 125-200gramm.
If, following “test for wet diapers, you find that your baby pees less 6raz or weekly gain he has less than 125 grams, and in doing so noted: anxiety child and cry during or immediately after feeding, the mother of feeling full discharge breast still in active nursing baby. It can assume a temporary shortage of milk (secondary gipolaktatsiya).
Her reasons:
• physical fatigue, nervous tension and anxiety the mother;
• poor latch (there is a painless option improper latch);
• incorrect organization of breastfeeding (feeding on the regime, the big night interruptions in feeding, dopaivanie water or something else, sucking pacifiers, bottle feeding, lactation aid, etc.);
• lactational crisis – this is a temporary decrease in milk.
Nursing crises often occur in the first 3 months of lactation, but sometimes happen in 7-8 months. Their frequency – about 1.5 months, the duration of 3-4 days, sometimes up to 6-8. for a child of such crisis does not pose danger.
What mum if stepped lactational crisis?
• respite from household chores, attention and assistance to relatives;
• Maximum body contact with the child;
• increase the number of latch, feeding on demand through the mother 1-1,5 hours;
• The use of additional funds to increase lactation (see additional funds to increase lactation).
Typically, these measures sufficient to lactation for 3-4 days to restore in full. It is unacceptable that at the beginning of the crisis has already made attempts to introduce lactation aid. Lactation is not will establish, and, conversely, will reduce. The main thing – to believe that you could do it.

Giperlaktatsiya (excess milk)

The main reasons giperlaktatsii: frequent changes of the breast; additional decantation after feeding; physiological reasons; stimulation of oxytocin during childbirth.
If giperlaktatsii must:
• establish a change of the breast. For one feeding to give the child only one breast. Apposition or 2-3 (if the intervals between feedings no more than 1,5-2 hours) to do one breast, and then 2.3 apposition to the other. With this method, the breast, which is “not working” can overflow. If this happens, it is possible during the next shift to feeding her baby for 2-5 minutes to suck a little milk, or Express breast that the breast, but only to facilitate the state, but not completely.
• some limited fluid intake and stop drinking laktogonnye means;
• wear a bra;

Lactostasis. Mastitis. Treatment.

These phenomena are easily confused, which often happens. Therefore, for the start will give them definition.
Lactostasis – a violation of the outflow of milk from the breast.
Symptoms: slight thickening in the breast, usually in one lobe, painful to the touch, easy porozovenie skin, with rastsezhivanii decreased in size or disappear, there may be a rise in body temperature.
Reasons: a long break in feeding; uncomfortable bra, suboccluding chest; use the same posture during feeding.
Mastitis – inflammation of the breast is infected.
Symptoms: “stone” seal covering a significant part of his chest is very painful, intense color (from red to cyanotic); rastsezhivaetsya with difficulty or not at all rastsezhivaetsya; body temperature is high, breaching the outflow of milk allocation drops of pus in rastsezhivanii.
Reasons: not cured lactostasis; long unhealed cracked nipples, the presence of her mother in the body of infection.
Treatment.
In the first painful sensation in the breast should respond immediately. In my practice, we use the following treatment regimens:
1.
2. (show)
3.
4.

OFFER! On medication. Summing up the results.
So ended our promotions and discounts on drugs. Thank you to all the participants of the shares. Promise and rot please you discount for our medical products. Though discounts and over, but our prices continue to please our customers, and remain among the lowest of medicines on the Internet. Once again I congratulate all of the holidays have passed. We wish you health and prosperity.

So ended our promotions and discounts on drugs. Thank you to all the participants of the shares. Promise and rot please you discount for our medical products. Though discounts and over, but our prices continue to please our customers, and remain among the lowest of medicines on the Internet. Once again I congratulate all of the holidays have passed. We wish you health and prosperity.

Company GlaxoSmithKline announced that the application (New Drug Application) for beta-blocker Coreg CR ™ (Carvedilol phosphate controlled-release capsules) taken in the FDA. On the 55 th annual scientific meeting of the American College of Cardiology (11-14 March 2006 Atlanta, USA) presented the results of a multicenter randomized double-blind, placebo-controlled clinical study of drugs used in doses of 20, 40 and 80 mg once daily for 6 weeks patients with arterial hypertension. Coreg CR ™ effectively reduce rates of blood pressure in these patients!

COREG BUY online CHEAP

Carvedilol (Carvedilol) in the form of tablets and tablet controlled release (Coreg, Coreg CR): FDA warns of risk of severe hypersensitivity reactions
According to data from FDA, patients receiving carvedilol therapy, occasionally observed hypersensitivity reactions (anaphylactic reaction, angioedema, urticaria).
Application of carvedilol is contraindicated in patients with severe hypersensitivity reactions (eg Stevens-Johnson syndrome, anaphylactic reaction, angioedema) to carvedilol in history.
FDA notes that patients receiving beta-blockers with severe anaphylactic reactions to various allergens in history may have more severe episodes of anaphylaxis upon repeated contact with the allergen. Such patients may be insensitive to the usual doses of epinephrine.
Carvedilol – antihypertensive means of a group of alpha-and beta-blockers without intrinsic sympathomimetic activity. Blocks α1-, β1-and β2-adrenergic receptors. As a result of the blockade β1-adrenoceptor moderately reduces the conductivity, strength and heart rate, without causing severe bradycardia. As a result of α1-adrenoceptor blockade causes expansion of peripheral vessels. Carvedilol is used to treat hypertension, angina, congestive heart failure (as part of combination therapy).

Carvedilol (Carvedilol) in the form of tablets and tablet controlled release (Coreg, Coreg CR): FDA warns of risk of severe hypersensitivity reactions

According to data from FDA, patients receiving carvedilol therapy, occasionally observed hypersensitivity reactions (anaphylactic reaction, angioedema, urticaria).

Application of carvedilol is contraindicated in patients with severe hypersensitivity reactions (eg Stevens-Johnson syndrome, anaphylactic reaction, angioedema) to carvedilol in history.

FDA notes that patients receiving beta-blockers with severe anaphylactic reactions to various allergens in history may have more severe episodes of anaphylaxis upon repeated contact with the allergen. Such patients may be insensitive to the usual doses of epinephrine.

Carvedilol – antihypertensive means of a group of alpha-and beta-blockers without intrinsic sympathomimetic activity. Blocks α1-, β1-and β2-adrenergic receptors. As a result of the blockade β1-adrenoceptor moderately reduces the conductivity, strength and heart rate, without causing severe bradycardia. As a result of α1-adrenoceptor blockade causes expansion of peripheral vessels. Carvedilol is used to treat hypertension, angina, congestive heart failure (as part of combination therapy).